Ectopeptidases: CD13/Aminopeptidase N and CD26/Dipeptidylpeptidase IV in Medicine and Biology Jürgen Langner

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Published: February 28th 2002

Kindle Edition

310 pages


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Ectopeptidases: CD13/Aminopeptidase N and CD26/Dipeptidylpeptidase IV in Medicine and Biology  by  Jürgen Langner

Ectopeptidases: CD13/Aminopeptidase N and CD26/Dipeptidylpeptidase IV in Medicine and Biology by Jürgen Langner
February 28th 2002 | Kindle Edition | PDF, EPUB, FB2, DjVu, AUDIO, mp3, RTF | 310 pages | ISBN: | 9.75 Mb

This book has a strong focus on the role APN and DPIV play in the hematopoietic system, where again signal peptides and small proteins (cytokines) are among the most interesting substrates. Additionally, both the membrane bound peptidases play rolesMoreThis book has a strong focus on the role APN and DPIV play in the hematopoietic system, where again signal peptides and small proteins (cytokines) are among the most interesting substrates. Additionally, both the membrane bound peptidases play roles as partners in signal transduction of lymphocytes and monocytes, and inhibition of their enzymatic activity results in cell cycle arrest, inhibition of DNA synthesis and characteristic changes of cytokine secretion pattern of T cells.

This knowledge more and more is used as the base of therapeutic strategies in the treatment of a variety of inflammatory and autoimmune diseases as well as of tumors of different origin. The editors themselves with their colleagues have contributed important results about APN and DPIV that are reviewed here, and additionally, most of the leading groups in this field from Europe, U.S., Australia and Japan have contributed reviews and latest, partially unpublished results of their work.



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